2,5-二氯-4-(3-硝基苯氧基)嘧啶合成路线 （共 4 条）
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Zhou, Wenjun; Ercan, Dalia; Jaenne, Pasi A.; Gray, Nathanael S.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 638 - 643
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Han, Chun; Wan, Ledong; Ji, Hongbin; Ding, Ke; Huang, Zhangjian; Lai, Yisheng; Peng, Sixun; Zhang, Yihua
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 75 - 83
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 2 h;
参考文献
DANA FARBER CANCER INSTITUTE; GRAY, Nathanael, S.; JANNE, Pasi; ECK, Michael, J.; ZHOU, Wenjun
Patent: WO2010/129053 A2, 2010 ;
Location in patent: Page/Page column 122-123 ;
WO 2010/129053 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 2 h; regioselective reaction;
参考文献
Han, Chun; Huang, Zhangjian; Zheng, Chao; Wan, Ledong; Zhang, Lianwen; Peng, Sixun; Ding, Ke; Ji, Hongbin; Tian, Jide; Zhang, Yihua
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4738 - 4748
