(3aS,4R,5S,6aR)-(+)-六氢-5-羟基-4-(羟甲基)-2H-环戊并[b]呋喃-2-酮合成路线 （共 58 条）
反应条件
1: With sodium hydroxide in water T=72°C; 3.5 h; 2: With hydrogenchloride in water T=0°C; pH=6.3;
参考文献
HANMI HOLDINGS CO., LTD.
Patent: US2011/251387 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1: With trifluoroacetic acid in tetrahydrofuran; water T=70 - 85°C; 1.5 h; 2: With ammonium hydroxide in water
参考文献
ScinoPharm Taiwan, Ltd.
Patent: US2011/201809 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With hydrogenchloride; water in dichloromethane T=20°C; 18 h; 2: With sodium hydroxide T=20°C; pH=7 - 8; 1 h;
参考文献
ALPHORA RESEARCH INC.; ALBERICO, Dino; CLAYTON, Joshua; DIXON, Craig; GORIN, Boris
Patent: WO2011/150512 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogenchloride; water in tetrahydrofuran Heating;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0356-0357 ;
反应条件
hydrogenchloride; water in tetrahydrofuran Reflux;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0358 ;
反应条件
hydrogenchloride; water in tetrahydrofuran Reflux;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0359 ;
反应条件
1: With hydrogenchloride; water in dichloromethane T=20°C; 18 h; 2: With sodium hydroxide T=20°C; pH=7 - 8; 0.75 h;
参考文献
ALPHORA RESEARCH INC.; ALBERICO, Dino; CLAYTON, Joshua; DIXON, Craig; GORIN, Boris
Patent: WO2011/150512 A1, 2011 ;
Location in patent: Page/Page column 9-10 ;
反应条件
hydrogenchloride; water in tetrahydrofuran 6 h; Reflux;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0351-0352 ;
反应条件
hydrogenchloride; water in tetrahydrofuran 8 h; Reflux;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0353-0355 ;
反应条件
sodium methylate in methanol T=20°C; 0.5 h; Inert atmosphere;
参考文献
ESTEVE QUÍMICA, S.A.; BERENGUER MAIMÓ, Ramón; BADIA PÉREZ, Laura; GASANZ GUILLÉN, Yolanda; VELASCO TURBAU, Javier; ARIZA PIQUER, Javier
Patent: WO2013/76236 A1, 2013 ;
Location in patent: Page/Page column 25 ;
