2-乙基噻唑-4-羧酸乙酯合成路线 （共 6 条）
反应条件
oxygen; copper diacetate in N,N-dimethyl-formamide T=120°C; P=760.051 Torr; 12 h; Molecular sieve;
参考文献
Wang, Yiyun; Li, Ziyuan; Huang, Yue; Tang, Changhua; Wu, Xiaoming; Xu, Jinyi; Yao, Hequan
Tetrahedron, 2011 , vol. 67, # 38 p. 7406 - 7411
反应条件
in ethanol 0.25 h; Heating;
参考文献
Akita, Hiroyuki; Sasaki, Takamitsu; Kato, Keisuke; Suzuki, Yoshihiro; Kondo, Keiko; Sakagami, Youji; Ojika, Makoto; Fudou, Ryosuke; Yamanaka, Shigeru
Tetrahedron, 2004 , vol. 60, # 21 p. 4735 - 4738
反应条件
1: With potassium acetate in methanol T=0°C; 4 h; 2: With manganese(IV) oxide in acetonitrile Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 9 p. 1279 - 1286
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3491 - 3495
反应条件
potassium hydroxide T=50°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/144494 A1, 2009 ;
Location in patent: Page/Page column 133 ;
WO 2009/144494 A1
反应条件
methanol; sodium tetrahydroborate
T=20°C;
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
Location in patent: Page/Page column 52 ;
