methanol; magnesium T=20°C; 1.5 h; Inert atmosphere;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '661212', constants.ctx, '0')">tris-(o-tolyl)phosphine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8136861', constants.ctx, '0')">lithium hexamethyldisilazane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '14221398', constants.ctx, '0')">tris(dibenzylideneacetone)dipalladium ⁽⁰⁾</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />T=100&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3589723', constants.ctx, '0')">N-methoxyamine hydrochloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3595639', constants.ctx, '0')">sodium acetate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />3&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506297', constants.ctx, '0')">methanesulfonyl chloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 18 percent / acetyl chloride / ethanol / 24 h / Heating<br />2: 91 percent / LiHMDS / Pd₂(dba)3; P(2-Tol)3 / toluene; tetrahydrofuran / 1.5 h / 100 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 18 percent / acetyl chloride / ethanol / 24 h / Heating<br />2: 91 percent / LiHMDS / Pd₂(dba)3; P(2-Tol)3 / toluene; tetrahydrofuran / 1.5 h / 100 &deg;C<br /> <br /> &nbsp;