甲基2,2-二乙氧基乙亚氨酸酯合成路线 （共 4 条）
反应条件
in methanol
T=20°C; 24 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; LLOYD, John; FINLAY, Heather; JIANG, Ji; NEELS, James; DHONDI, Naveen Kumar; GUNAGA, Prashantha; BANERJEE, Abhisek; ADISECHAN, Ashokkumar
Patent: WO2011/28741 A1, 2011 ;
Location in patent: Page/Page column 341 ;
WO 2011/028741 A1
反应条件
carbon dioxide; sodium methylate in methanol; diethyl ether
参考文献
AstraZeneca AB
Patent: US7235559 B1, 2007 ;
US 7235559 B1
参考文献
Zhang, Lei; Rogers, Bruce N.; Duplantier, Allen J.; McHardy, Stanley F.; Efremov, Ivan; Berke, Helen; Qian, Weimin; Zhang, Andy Q.; Maklad, Noha; Candler, John; Doran, Angela C.; Lazzaro Jr., John T.; Ganong, Alan H.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5493 - 5496
反应条件
1: 4,5-difluoro-2-nitro-phenylamine With hydrogen; palladium 10 on activated carbon in methanol
T=20°C; 3 h;
2: 2,2-diethoxy-ethanimidic acid methyl ester With acetic acid in methanol
T=20°C; 16 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12623 A1, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/012623 A1
