丁氧羰基-D-酪氨酸-甲氧基酯合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in ethanol T=20°C;
参考文献
ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; BUZARD, Daniel J.; LEHMANN, Juerg; NARAYANAN, Sanju; YUE, Dawei
Patent: WO2011/127051 A1, 2011 ;
Location in patent: Page/Page column 191 ;
WO 2011/127051 A1
反应条件
sodium hydrogencarbonate in ethanol
参考文献
Hulme, Alison N.; Rosser, Edward M.
Organic Letters, 2002 , vol. 4, # 2 p. 265 - 267
反应条件
1: thionyl chloride / 20 h / Heating 2: triethylamine / methanol / 17 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 96 percent / pyridine / CH2Cl2 / 0.08 h / -15 °C 2: 100 percent / potassium carbonate / tetrakis(triphenylphosphine)palladium(0) / toluene / 2 h / 80 °C View Scheme
参考文献
Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700
反应条件
1: potassium carbonate; potassium iodide / acetone / 4 h / Heating 2: sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: K2CO3, 18-crown-6 / benzene / 1.5 h / Heating 2: NaOH / methanol; H2O / 0.5 h View Scheme
参考文献
Kolodziejczyk; Manning
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1944 - 1946
反应条件
lithium hydroxide in methanol; water T=20°C; Hydrolysis;
参考文献
Quagliato, Dominick A.; Andrae, Patrick M.; Matelan, Edward M.
Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 5037 - 5042
反应条件
crown ether in N,N-dimethyl-formamide; benzene 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 1 p. 45 - 50
反应条件
1: K2CO3, 18-crown-6 / benzene / 1.5 h / Heating 2: NaOH / methanol; H2O / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 9 p. 1944 - 1946
反应条件
1: 96 percent / pyridine / CH2Cl2 / 0.08 h / -15 °C
2: 100 percent / potassium carbonate / tetrakis(triphenylphosphine)palladium(0) / toluene / 2 h / 80 °C
3: 95 percent / 1 N aq. NaOH / tetrahydrofuran; methanol / Ambient temperature
4: 97 percent / triethylamine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride, hydroxybenzotriazole / CH2Cl2 / 16 h / Ambient temperature
5: 100 percent / LiAlH4 / diethyl ether / 0.33 h / 0 °C
6: 78 percent / CH2Cl2 / 16 h / Ambient temperature
7: 9.5 percent / H2 / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr
8: 95 percent / HCl (gas) / CH2Cl2 / 5 h / Ambient temperature
9: pyridine / CH2Cl2 / 16 h / Ambient temperature
10: toluene / 1 h / 80 °C
11: HCl (gas) / CH2Cl2 / 16 h / Ambient temperature
View Scheme
参考文献
Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700
