1: p-toluidine; acetone With gallium(III) tetrafluoroethanesulfonate in dichloromethane
T=50°C; Strecker Aminoacid Synthesis; 8 h;
2: trimethylsilyl cyanide in dichloromethane
T=20°C;
参考文献
Prakash, G. K. Surya; Mathew, Thomas; Panja, Chiradeep; Kulkarni, Aditya; Olah, George A.; Harmer, Mark A.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2163 - 2171
Rajabi, Fatemeh; Nourian, Saghar; Ghiassian, Sara; Balu, Alina M.; Saidi, Mohammad Reza; Serrano-Ruiz, Juan Carlos; Luque, Rafael
Green Chemistry, 2011 , vol. 13, # 11 p. 3282 - 3289
1: With titanium(IV) isopropylate; (1R,2S)-2-(N-2-hydroxyl-3-methylbenzyl)amino-1,2-diphenyl-1-ethanol in dichloromethane; toluene
T=-20°C; 16 h;
2: With hydrogenchloride in methanol; water
T=20°C; 4 h; Title compound not separated from byproducts;
参考文献
Lin, Zheng-Chang; Chen, Chinpiao
Journal of the Chinese Chemical Society, 2010 , vol. 57, # 4 A p. 726 - 737
titanium tetra-n-butoxide; water; N-(2'-hydroxyphenyl)methyl-(S)-2-amino-3,3-dimethyl-butan-1-ol in toluene; butan-1-ol
T=20°C; 0.25 h; optical yield given as percent eeenantioselective reaction;
参考文献
Seayad, Abdul Majeed; Ramalingam, Balamurugan; Yoshinaga, Kazuhiko; Nagata, Takushi; Chai, Christina L. L.
Organic Letters, 2010 , vol. 12, # 2 p. 264 - 267
1: With bis(trimethylsilyl)-peroxide in 1,2-dichloro-ethane
T=50°C; 48 h;
2: With potassium fluoride in methanol
Further stages. Title compound not separated from byproducts.;
参考文献
Yamasaki; Kanai; Shibasaki
Journal of the American Chemical Society, 2001 , vol. 123, # 6 p. 1256 - 1257
