2,2,6,6-四甲基哌啶合成路线 （共 107 条）
反应条件
1: 2,2,6,6-tetramethyl-piperidine With n-butyllithium in tetrahydrofuran; hexane
T=-10°C;
2: tri-isopropoxy-borane; benzonitrile in tetrahydrofuran; hexane
T=-78°C; 2 h;
3: With water; ammonium chloride in tetrahydrofuran; hexane
T=20°C;
参考文献
Nakamura, Shinichiro
Patent: US2009/184289 A1, 2009 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: 2,2,6,6-tetramethyl-piperidine; benzonitrile With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran
T=-78 - 20°C;
2: 3-hydroxy-2,2-dimethylpropanol in toluene
T=20°C;
参考文献
Kristensen, Jesper; Lysen, Morten; Vedso, Per; Begtrup, Mikael
Organic Letters, 2001 , vol. 3, # 10 p. 1435 - 1437
反应条件
tert.-butylhydroperoxide; zinc dibromide in pyridine; water
T=80°C; 16 h;
参考文献
Wu, Xiao-Feng; Bheeter, Charles Beromeo; Neumann, Helfried; Dixneuf, Pierre H.; Beller, Matthias
Chemical Communications, 2012 , vol. 48, # 100 p. 12237 - 12239
反应条件
n-butyllithium
1.) hexane, THF, -78 deg C, 10 min; -15 deg C, 10 min, 2.) THF, -15 deg; Yield given. Multistep reaction;
参考文献
Ikehira, Hideyuki; Tanimoto, Shigeo
Synthesis, 1983 , # 9 p. 716 - 717
反应条件
1: 2,2,6,6-tetramethyl-piperidine With n-butyllithium in tetrahydrofuran; hexane
T=-10°C; 0.166667 h;
2: tri-isopropoxy-borane; alpha-chloronaphthalene in tetrahydrofuran; hexane
T=-78 - 20°C;
3: 3-hydroxy-2,2-dimethylpropanol With acetic acid in tetrahydrofuran; hexane
T=20°C; 1 h; Further stages.;
参考文献
Lysen, Morten; Madden, Maurice; Kristensen, Jesper Langgaard; Vedso, Per; Zoellner, Camilla; Begtrup, Mikael
Synthesis, 2006 , # 20 p. 3478 - 3484
反应条件
hydrogenchloride in 1,4-dioxane
Inert atmosphere;
参考文献
Saper, Noam I.; Snider, Barry B.
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 809 - 813
反应条件
sulfuryl dichloride in chloroform-d1
Inert atmosphere; Solvent;
参考文献
Saper, Noam I.; Snider, Barry B.
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 809 - 813
反应条件
in dichloromethane
12 h; Ambient temperature;
参考文献
Branchaud, Bruce P.
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3538 - 3544
反应条件
1: 98 percent / aq. HCl; NaNO2 / 75 - 100 °C
2: 73 percent / LiAlH4 / dibutyl ether / 3 h / 95 °C
View Scheme
参考文献
Hinsberg, William D.; Schultz, Peter G.; Dervan, Peter B.
Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 766 - 773
反应条件
peracetic acid; potassium carbonate; acetic acid in dichloromethane; water
参考文献
Detrembleur, Christophe; Gross, Thomas; Meyer, Rolf-Volker
Patent: US2003/236368 A1, 2003 ;
Location in patent: Page 9 ;
