2,2,6,6-四甲基哌啶合成路线 （共 107 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 3 h; 2: With tri-isopropoxy-borane T=-78°C; 0.5 h; 3: With hydrogenchloride T=20°C; 1 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/41826 A1, 2004 ;
Location in patent: Page 35 ;
反应条件
chlorine; sodium hydroxide in water T=5 - 20°C; 1.5 h; Inert atmosphere; Reagent/catalystTime;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; FORD, Mark James
Patent: WO2013/120874 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
sulfuryl dichloride in chloroform-d1 Inert atmosphere; Solvent;
参考文献
Saper, Noam I.; Snider, Barry B.
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 809 - 813
反应条件
1: 2,2,6,6-tetramethyl-piperidine With potassium carbonate in acetonitrile T=85°C; 1 h; Inert atmosphere; 2: ethyl iodide 48 h; Inert atmosphereReflux;
参考文献
Jiang, Chunfang; Blacque, Olivier; Fox, Thomas; Berke, Heinz
Organometallics, 2011 , vol. 30, # 8 p. 2117 - 2124
参考文献
Hall
Journal of the American Chemical Society, 1957 , vol. 79, p. 5439
反应条件
in dichloromethane (CF3SO2)2O added to a stirred soln. of CpRe(NO)(PPh3)(COCH3) in CH2Cl2 at -78°C, after 10 min addn. of TMP, stirring for 1 h at -78°C, (CF3SO2)2O added, after 10 min soln. warmed to room temp., filtration, solvent removed by rotary evapn.;; extn. (CHCl3), extract filtered, solvent removed by rotary evapn.; monitored by (1)H- and (31)P-NMR-spectroscopy (-80°C, CD2Cl2 or CH2Cl2, < 5 min);;
参考文献
Senn,D.R.; Wong,A.; Patton,A.T.
Journal of the American Chemical Society, 1988 , vol. 110, p. 6096
反应条件
in dichloromethane react. monitored by (1)H- and (31)P-NMR-spectroscopy (-80°C, CD2Cl2 or CH2Cl2, < 5 min); sc/ac-ratio>99:1; elem. anal.;;
参考文献
Senn,D.R.; Wong,A.; Patton,A.T.
Journal of the American Chemical Society, 1988 , vol. 110, p. 6096
反应条件
in dichloromethane react. monitored by (1)H- and (31)P-NMR-spectroscopy (-80°C, CD2Cl2 or CH2Cl2, < 5 min); elem. anal.; sc/ac-ratio>99:1;;
参考文献
Senn,D.R.; Wong,A.; Patton,A.T.
Journal of the American Chemical Society, 1988 , vol. 110, p. 6096
反应条件
NaOH; concentrated HCl in n-butyllithium; ethanol; hexane
参考文献
Novo Nordisk A/S
Patent: US5182283 A1, 1993 ;
反应条件
1: 2,2,6,6-tetramethyl-piperidine; benzonitrile With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2: 3-hydroxy-2,2-dimethylpropanol in toluene T=20°C;
参考文献
Organic Letters, , vol. 3, # 10 p. 1435 - 1437
