2,2,6,6-四甲基哌啶合成路线 （共 107 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane; cyclohexanone
参考文献
Merck and Co., Inc.
Patent: US6284755 B1, 2001 ;
US 6284755 B1
反应条件
n-butyllithium in tetrahydrofuran; hexane
反应条件
1.1: potassium carbonate; potassium iodide / pentan-3-one / 48 h / Reflux 2.1: tert.-butyl lithium / pentane; tetrahydrofuran / 2.5 h / -78 °C 2.2: 3 h / 20 °C View Scheme
参考文献
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
Patent: US2011/319620 A1, 2011 ;
反应条件
in tetrahydrofuran T=-78°C; Equilibrium constant;
参考文献
Ahlbrecht, Hubertus; Schneider, Gunther
Tetrahedron, 1986 , vol. 42, # 17 p. 4729 - 4742
反应条件
n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran
参考文献
Monsanto Company
Patent: US5498630 A1, 1996 ;
反应条件
Oxonereg;; silica gel in water
T=80°C; Oxidation; 24 h;
参考文献
Fields, John D.; Kropp, Paul J.
Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 5937 - 5941
反应条件
dipotassium hydrogenphosphate; N,N-dimethyl-formamide
T=25°C; Inert atmosphere;
参考文献
Rucker, Richard P.; Whittaker, Aaron M.; Dang, Hester; Lalic, Gojko
Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3953 - 3956
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
John Wyeth and Brother Limited
Patent: US4296029 A1, 1981 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Merck and Co., Inc.
Patent: US6284755 B1, 2001 ;
US 6284755 B1
反应条件
1: 2,2,6,6-tetramethyl-piperidine With sodium hydride in toluene
T=20°C; 0.166667 h;
2: benzoyl chloride in toluene
24 h; Heating;
参考文献
Clayden, Jonathan; Foricher, Yann J. Y.; Lam, Ho Kam
European Journal of Organic Chemistry, 2002 , # 21 p. 3558 - 3565
