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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
合成路线
（共 10 条）
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-52-8
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: 81 percent / 1 N NaOH / 10 h / Heating View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-55-1
2,4-二氯-吡啶并(3,2-d)嘧啶-6-甲醇乙酸酯(酯)
反应条件
triethylamine; trichlorophosphate 8 h; Reflux;
参考文献
Zhang, Zhili; Wu, Jun; Ran, Fuxiang; Guo, Ying; Tian, Ran; Zhou, Shouxin; Wang, Xiaowei; Liu, Zhenming; Zhang, Liangren; Cui, Jingrong; Liu, Junyi
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 764 - 771
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-56-2
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h View Scheme
参考文献
Gangjee, Aleem; Zhu, Yuanming; Queener, Sherry F.; Francom, Paula; Broom, Arthur D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1836 - 1845
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-63-1
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: N,N-dimethyl-acetamide / 72 h / Ambient temperature 5: 72 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Zhang, Zhili; Tian, Chao; Zhou, Shouxin; Wang, Wei; Guo, Ying; Xia, Jie; Liu, Zhenming; Wang, Biao; Wang, Xiaowei; Golding, Bernard T.; Griff, Roger J.; Du, Yansheng; Liu, Junyi
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 228 - 236
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-64-2
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 5: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-68-6
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: 81 percent / 1 N NaOH / 10 h / Heating 4: PBr3 / tetrahydrofuran / 12 h 5: N,N-dimethyl-acetamide / 6 h / Heating 6: 58 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76807-69-7
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: 81 percent / 1 N NaOH / 10 h / Heating 4: PBr3 / tetrahydrofuran / 12 h 5: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h 6: 72 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76822-61-2
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C View Scheme
参考文献
Gangjee, Aleem; Zhu, Yuanming; Queener, Sherry F.; Francom, Paula; Broom, Arthur D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1836 - 1845
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76822-62-3
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: N,N-dimethyl-acetamide / 6 h / Heating 5: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Zhang, Zhili; Tian, Chao; Zhou, Shouxin; Wang, Wei; Guo, Ying; Xia, Jie; Liu, Zhenming; Wang, Biao; Wang, Xiaowei; Golding, Bernard T.; Griff, Roger J.; Du, Yansheng; Liu, Junyi
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 228 - 236
76807-54-0
{2,4-二羟基吡啶并[3,2-d]嘧啶-6-基}甲基乙酸酯
→
反应条件
76822-63-4
反应条件
1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h 5: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
