2,4-二氯-吡啶并(3,2-d)嘧啶-6-甲醇乙酸酯(酯)合成路线 （共 11 条）
反应条件
triethylamine; trichlorophosphate
8 h; Reflux;
参考文献
Zhang, Zhili; Wu, Jun; Ran, Fuxiang; Guo, Ying; Tian, Ran; Zhou, Shouxin; Wang, Xiaowei; Liu, Zhenming; Zhang, Liangren; Cui, Jingrong; Liu, Junyi
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 764 - 771
反应条件
1: 85 percent / acetic acid / 0.5 h / Heating
2: 62 percent / POCl3, (C2H5)3N / 8 h / Heating
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: 81 percent / 1 N NaOH / 10 h / Heating
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: liq. NH3 / 150 - 160 °C
2: PBr3 / tetrahydrofuran
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: PBr3 / tetrahydrofuran / 8 h
3: N,N-dimethyl-acetamide / 72 h / Ambient temperature
4: 72 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Zhang, Zhili; Tian, Chao; Zhou, Shouxin; Wang, Wei; Guo, Ying; Xia, Jie; Liu, Zhenming; Wang, Biao; Wang, Xiaowei; Golding, Bernard T.; Griff, Roger J.; Du, Yansheng; Liu, Junyi
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 228 - 236
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: PBr3 / tetrahydrofuran / 8 h
3: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h
4: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: 81 percent / 1 N NaOH / 10 h / Heating
3: PBr3 / tetrahydrofuran / 12 h
4: N,N-dimethyl-acetamide / 6 h / Heating
5: 58 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: 81 percent / 1 N NaOH / 10 h / Heating
3: PBr3 / tetrahydrofuran / 12 h
4: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h
5: 72 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
ammonia
T=160 - 170°C; 18 h;
参考文献
Srinivasan, Ananthachari; Broom, Arthur D.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1777 - 1781
反应条件
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: PBr3 / tetrahydrofuran / 8 h
3: N,N-dimethyl-acetamide / 6 h / Heating
4: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Zhang, Zhili; Tian, Chao; Zhou, Shouxin; Wang, Wei; Guo, Ying; Xia, Jie; Liu, Zhenming; Wang, Biao; Wang, Xiaowei; Golding, Bernard T.; Griff, Roger J.; Du, Yansheng; Liu, Junyi
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 228 - 236
