sodium hydroxide in ethanol 48 h; Ambient temperature;

1: 85 percent / acetic acid / 0.5 h / Heating 2: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 3: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 4: PBr3 / tetrahydrofuran / 8 h 5: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 6: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 2: PBr3 / tetrahydrofuran / 8 h 3: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 4: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 5: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: PBr3 / tetrahydrofuran / 8 h 2: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 3: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 2: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 79 percent / liquid NH3 / 18 h / 160 - 170 °C 2: PBr3 / tetrahydrofuran / 8 h 3: 1.) NaOC2H5 / 1.) ethanol, room temperature, 1 h, 2.) dimethylacetamide, room temperature, 10 h 4: 62 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme