4-(4-氯-1-氧代丁基)-alpha,alpha-二甲基苯乙酸乙酯合成路线 （共 12 条）
反应条件
hydrogenchloride in ethanol; xylene T=70°C; 220 h;
参考文献
US6340761 B1, ;
Page column 49 ;
反应条件
hydrogenchloride in ethanol 2.5 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 79 ;
反应条件
hydrogenchloride in dichloromethane
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6242606 B1, 2001 ;
反应条件
aluminium trichloride in dichloromethane T=10 - 20°C; Heating / reflux;
参考文献
US6340761 B1, ;
Page column 51 ;
反应条件
AlCl3, aluminium chloride in dichloromethane T=10 - 90°C; 2.5 h;
参考文献
US6348597 B2, ;
Page column 56 ;
反应条件
hydrogenchloride T=60°C; 2.5 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Example 27 ;
反应条件
hydrogenchloride T=40 - 45°C; 7 h;
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
反应条件
1.1: AlCl3, aluminium chloride; Propylene glycol / methyl acetate / 0 - 5 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 2.33 h / -5 - 0 °C 2.2: 5 h / 0 °C 3.1: methanol; sodium hydroxide / 4 h / 25 - 30 °C 4.1: water; acetic acid; potassium permanganate / acetone / 7 h / 25 - 45 °C 5.1: hydrogenchloride / 7 h / 40 - 45 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 39, # 5 p. 2149 - 2155
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 2.33 h / -5 - 0 °C 1.2: 5 h / 0 °C 2.1: methanol; sodium hydroxide / 4 h / 25 - 30 °C 3.1: water; acetic acid; potassium permanganate / acetone / 7 h / 25 - 45 °C 4.1: hydrogenchloride / 7 h / 40 - 45 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 39, # 5 p. 2149 - 2155
反应条件
1: methanol; sodium hydroxide / 4 h / 25 - 30 °C 2: water; acetic acid; potassium permanganate / acetone / 7 h / 25 - 45 °C 3: hydrogenchloride / 7 h / 40 - 45 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 39, # 5 p. 2149 - 2155
