1: With toluene-4-sulfonic acid; PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in ethanol T=20°C; 24 h; 2: With sodium hydroxide in tetrahydrofuran T=20°C; 24 h; Heating; 3: With acetic acid in tetrahydrofuran Product distribution / selectivity;

1: With sulfuric acid; mercury(II) oxide in methanol; water T=40°C; 2: With water; sodium hydroxide in methanol 3: With acetic acid in methanol Reflux;

Streptomyces platensis NRRL 2364 in N,N-dimethyl-formamide T=30°C; pH=5; 35 h; aq. bufferMicrobiological reaction;

1: With sodium hydroxide in water; isopropyl alcohol 5 h; Heating / reflux; 2: With acetic acid in water; isopropyl alcohol pH=5.5 - 6;

1.1: ammonia / toluene; water / pH 9 2.1: mercury(II) oxide; sulfuric acid / water; methanol / 40 °C 2.3: Reflux View Scheme

1: With hydrogen; palladium on activated carbon in methanol; water T=50°C; P=4500.45 - 7500.75 Torr; 2: With acetic acid in methanol; water pH=5 - 8; Product distribution / selectivity;

1: With methanol; sodium hydroxide; water T=40°C; 2: With sodium tetrahydroborate in methanol; water 3: With hydrogenchloride in methanol; water; acetone pH=2.5 - 3;