sodium hydroxide in tetrahydrofuran T=20°C; 2 h;

1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 2: PBr3 / tetrahydrofuran / 8 h 3: N,N-dimethyl-acetamide / 6 h / Heating 4: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 2: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 3: PBr3 / tetrahydrofuran / 8 h 4: N,N-dimethyl-acetamide / 6 h / Heating 5: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: PBr3 / tetrahydrofuran / 8 h 2: N,N-dimethyl-acetamide / 6 h / Heating 3: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: N,N-dimethyl-acetamide / 6 h / Heating 2: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 85 percent / acetic acid / 0.5 h / Heating 2: 62 percent / POCl3, (C2H5)3N / 8 h / Heating 3: 84 percent / liquid NH3 / 18 h / 160 - 170 °C 4: PBr3 / tetrahydrofuran / 8 h 5: N,N-dimethyl-acetamide / 6 h / Heating 6: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: 79 percent / liquid NH3 / 18 h / 160 - 170 °C 2: PBr3 / tetrahydrofuran / 8 h 3: N,N-dimethyl-acetamide / 6 h / Heating 4: 68 percent / 1 N NaOH / ethanol / 48 h / Ambient temperature View Scheme

1: N,N-dimethyl acetamide / 2 h / 20 °C 2: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C View Scheme