3-(2-胍基-噻唑-4-基甲硫)-丙腈合成路线 （共 8 条）
反应条件
ammonia; ammonium chloride in methanol T=80 - 90°C; 15 h;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 87.3 percent / acetone / 5 h / Heating 2: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C 3: 89.9 percent / ethanol / 1 h / Heating 4: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
1: 89.9 percent / ethanol / 1 h / Heating 2: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
1: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C 2: 89.9 percent / ethanol / 1 h / Heating 3: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
hydrogenchloride in N,N-dimethyl-formamide T=4°C; 48 h;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
2: 70.7 percent / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
2: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
