3-(((胍基-4-噻唑基)甲基)硫)丙亚氨酸甲酯合成路线 （共 11 条）
反应条件
hydrogenchloride in N,N-dimethyl-formamide T=4°C; 48 h;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 87.3 percent / acetone / 5 h / Heating 2: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C 3: 89.9 percent / ethanol / 1 h / Heating 4: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C 5: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
1: 89.9 percent / ethanol / 1 h / Heating 2: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C 3: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
1: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C 2: 89.9 percent / ethanol / 1 h / Heating 3: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C 4: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
1: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C 2: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 7 p. 849 - 857
反应条件
amidosulfamic acid in methanol 2 h; Heating;
参考文献
Yanagisawa, Isao; Hirata, Yasufumi; Ishii, Yoshio
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1787 - 1793
反应条件
amidosulfamic acid in methanol 47 h; Ambient temperature;
参考文献
Yanagisawa, Isao; Hirata, Yasufumi; Ishii, Yoshio
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1787 - 1793
反应条件
1: 54.7 percent / H2NSO2NH2 / methanol / 47 h / Ambient temperature 2: 75.3 percent / conc. HCl / 2 h / Heating View Scheme
参考文献
Yanagisawa, Isao; Hirata, Yasufumi; Ishii, Yoshio
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1787 - 1793
反应条件
in methanol
0.5 h; Ambient temperature;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
water in ethanol
T=40°C; 20 h;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
