3-[[[2-[(氨基亚胺甲基)氨基]-4-噻唑基]甲基]硫基]丙酰胺合成路线 (共 7 条)
反应条件
water in ethanol
T=40°C; 20 h;
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 87.3 percent / acetone / 5 h / Heating
2: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C
3: 89.9 percent / ethanol / 1 h / Heating
4: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C
5: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
6: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
2: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 89.9 percent / ethanol / 1 h / Heating
2: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C
3: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
4: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 93.5 percent / aq. K2CO3 / acetone; methanol / 5 h / 50 °C
2: 89.9 percent / ethanol / 1 h / Heating
3: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C
4: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
5: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
1: 51.45 percent / ammonia, NH4Cl / methanol / 15 h / 80 - 90 °C
2: 81.8 percent / HCl / dimethylformamide / 48 h / 4 °C
3: 67.5 percent / water / ethanol / 20 h / 40 °C
View Scheme
参考文献
Yanagisawa; Hirata; Ishii
Journal of medicinal chemistry, 1984 , vol. 27, # 7 p. 849 - 857
反应条件
Soersen buffer in methanol
T=55°C; Decomposition; pH=1.71; Kinetics; Further Variations:TemperaturespH-values;
参考文献
Junnarkar; Stavchansky
Pharmaceutical Research, 1995 , vol. 12, # 4 p. 599 - 604