1,2,3,4-四氢-6-羟基异喹啉-3-羧酸合成路线 （共 5 条）
反应条件
water T=20°C; Picted-Spengler reaction;
参考文献
Sperlinga, Emanuela; Kosson, Piotr; Urbanczyk-Lipkowska, Zofia; Ronsisvalle, Giuseppe; Carr, Daniel B.; Lipkowski, Andrzej W.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2467 - 2469
反应条件
hydrogenchloride 0.75 h; Heating;
参考文献
Ornstein; Arnold; Augenstein; Paschal
Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4388 - 4392
反应条件
hydrogenchloride Heating;
参考文献
Ornstein; Arnold; Augenstein; Paschal
Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4388 - 4392
参考文献
PFIZER JAPAN, INC.; PFIZER, Inc.
Patent: WO2005/16913 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/016913 A1
反应条件
diisopropylamine in 1,4-dioxane; water
T=20°C; 60 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; PEREZ, Heidi L.; STANG, Erik M.; KIM, Kyoung S.
Patent: WO2013/192286 A1, 2013 ;
Location in patent: Paragraph 00216 ;
