S-(3)-羟基肉豆蔻酸甲酯合成路线 （共 22 条）
反应条件
Porcine Pancreas Lipase; water in aq. phosphate buffer
T=36°C; pH=7.6; 7 h; Resolution of racemate; enantioselective reaction;
参考文献
Kuecuek, Hatice Baspinar; Yusufoglu, Ayse
Monatshefte fur Chemie, 2013 , vol. 144, # 7 p. 1087 - 1091
反应条件
immobilized lipase (Amano PS) in tetrahydrofuran
T=26 - 28°C; Acetylation; 120 h; Title compound not separated from byproducts;
参考文献
Liu, Wen-Chi; Oikawa, Masato; Fukase, Koichi; Suda, Yasuo; Winarno, Hendig; Mori, Saeko; Hashimoto, Masahito; Kusumoto, Shoichi
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 6 p. 1441 - 1450
反应条件
1: lipase(Amano PS) / tetrahydrofuran
2: 6M HCl / methanol / 40 °C
View Scheme
参考文献
Fukase, Koichi; Liu, Wen-Chi; Suda, Yasuo; Oikawa, Masato; Wada, Akira; Mori, Saeko; Ulmer, Arthur J.; Rietschel, Ernst Th.; Kusumoto, Shoichi
Tetrahedron Letters, 1995 , vol. 36, # 41 p. 7455 - 7458
反应条件
1: 1.4 eq. R-Alpine-Borane / neat (no solvent) / 8 h / 0 - 20 °C
2: 1) 2.4 eq. n-BuLi; 2) 1.4 M H2SO4 / 1) THF, -78 deg C; 2) from -20 deg C to room temperature
3: 1) 2 eq. dicyclohexylborane; 2) NaOH, H2O2 / 1) THF, 0 deg C; 2) 40-50 deg C
4: HCl / 2 h / Ambient temperature
View Scheme
参考文献
Pons; Kocienski
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1833 - 1836
反应条件
1: 1) 2.4 eq. n-BuLi; 2) 1.4 M H2SO4 / 1) THF, -78 deg C; 2) from -20 deg C to room temperature
2: 1) 2 eq. dicyclohexylborane; 2) NaOH, H2O2 / 1) THF, 0 deg C; 2) 40-50 deg C
3: HCl / 2 h / Ambient temperature
View Scheme
参考文献
Pons; Kocienski
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1833 - 1836
反应条件
1: 1) 2 eq. dicyclohexylborane; 2) NaOH, H2O2 / 1) THF, 0 deg C; 2) 40-50 deg C
2: HCl / 2 h / Ambient temperature
View Scheme
参考文献
Pons; Kocienski
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1833 - 1836
反应条件
Geotrichum candidum lipase
参考文献
Feichter, C.; Faber, K.; Griengl, H.
Tetrahedron Letters, 1989 , vol. 30, # 5 p. 551 - 552
反应条件
hydrogenchloride
2 h; Ambient temperature; Yield given. Title compound not separated from byproducts;
参考文献
Pons; Kocienski
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1833 - 1836
反应条件
vinyl acetate
1.) lipase PS-30, THF, 60 deg C, 24 h, 2.) ether; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sugai, Takeshi; Ritzen, Helena; Wong, Chi-Huey
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1051 - 1058
反应条件
4-(a-D-Glucosido)-D-glucose
1.) yeast Saccharomyces serevisiae IFO 0565, phosphate buffer (pH 7.6), 30 deg C, 24 h, 2.) Et2O; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mochizuki; Sugai; Ohta
Bioscience, Biotechnology and Biochemistry, 1994 , vol. 58, # 9 p. 1666 - 1670
