7-(苄氧基)-N-(4-溴-2-氟苯基)-6-甲氧基喹唑啉-4-胺合成路线 （共 12 条）
反应条件
1.1: acetic acid / 0.17 h / 90 °C
1.2: 1 h / Reflux
2.1: 1,4-dioxane / 12 h / Reflux
2.2: 3 h / Reflux
3.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux
4.1: isopropyl alcohol / 2 h / Reflux
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C
2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C
3.1: oxalyl dichloride / toluene / 2 h / Reflux
3.2: 2 h
4.1: acetic acid / 0.17 h / 90 °C
4.2: 1 h / Reflux
5.1: 1,4-dioxane / 12 h / Reflux
5.2: 3 h / Reflux
6.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux
7.1: isopropyl alcohol / 2 h / Reflux
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
