2-乙烯基环丙烷-1,1-二羧酸二乙酯合成路线 （共 30 条）
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran
T=0°C; 2 h; Inert atmosphere;
2: 1,4-trans-dibromo-2-butene in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Sherry, Benjamin D.; Fuerstner, Alois
Chemical Communications, 2009 , # 46 p. 7116 - 7118
反应条件
potassium carbonate in benzene
T=70 - 75°C; 10 h;
参考文献
Vardapetyan, A. A.; Khachatryan, D. S.; Panosyan, G. A.; Morlyan, N. M.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2034 - 2037
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2266 - 2270
反应条件
potassium carbonate in benzene
T=70 - 75°C; 10 h;
参考文献
Vardapetyan, A. A.; Khachatryan, D. S.; Panosyan, G. A.; Morlyan, N. M.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2034 - 2037
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2266 - 2270
参考文献
Emery Industries, Inc.
Patent: US4252739 A1, 1981 ;
参考文献
Emery Industries, Inc.
Patent: US4380656 A1, 1983 ;
反应条件
1: diethyl malonate With sodium ethanolate in ethanol; toluene
T=20°C; 0.5 h;
2: (E)-1,4-ditosyloxybut-2-ene in ethanol; toluene
T=20°C; 23 h;
3: With sodium hydroxide in water; toluene
T=20°C; 1 h; Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2537825 A1, 2012 ;
Location in patent: Page/Page column 26 ;
参考文献
Birch et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1390
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Skinner et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 1648
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Kierstead et al.
Journal of the Chemical Society, 1952 , p. 3616,3619
参考文献
Yannoni, Costantino S.; Macho, Volker; Myhre, Philip C.
Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 907 - 909
反应条件
lithium hydride in N,N-dimethyl-formamide
multistep react.; other bases, solvents, reaction times; other substrates; Product distribution;
参考文献
Depres, Jean-Pierre; Greene, Andrew E.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 928 - 931
反应条件
in tetrahydrofuran; mineral oil
T=20 - 50°C; 4.5 h; Inert atmosphere;
参考文献
Fang; Hu; Ren; Wang
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1479 - 1487
