1-苄基-4-(2-羟乙基)哌啶合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Synthetic Communications, , vol. 33, # 13 p. 2329 - 2338
反应条件
1-methyl-pyrrolidin-2-one; caesium carbonate T=150°C; 15 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 2 p. 461 - 463
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Dutta; Xu; Reith
Journal of Medicinal Chemistry, 1996 , vol. 39, # 3 p. 749 - 756
反应条件
triethylamine in dichloromethane; water; dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US6303593 B1, 2001 ;
US 6303593 B1
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2, from -65 deg C to -60 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to RT, 6 h; Yield given. Multistep reaction;
参考文献
Luo, Zonghua; Sheng, Jianfei; Sun, Yang; Lu, Chuanjun; Yan, Jun; Liu, Anqiu; Luo, Hai-Bin; Huang, Ling; Li, Xingshu
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9089 - 9099
