1: 84 percent / DEAD, PPh3 / tetrahydrofuran / Ambient temperature 2: 55 percent / tributyltin hydride, AIBN / toluene / Heating View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -65 °C / Inert atmosphere 1.2: 3 h / 20 °C / Inert atmosphere 2.1: potassium borohydride; lithium chloride / tetrahydrofuran / 12 h / 35 °C 3.1: 1H-imidazole / dichloromethane / 1 h / 20 °C 4.1: pyridinium chlorochromate / dichloromethane / 12 h / 20 °C 5.1: titanium tetrachloride; zinc; 1,1-dibromomethane / tetrahydrofuran; dichloromethane / 5 h / -40 - 20 °C 6.1: K2OsO4*2H2O; methanesulfonamide; potassium carbonate; (DHQ)2PHAL; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 40 h / 0 - 20 °C 7.1: sodium chlorite; sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / water; acetonitrile / 5 h / 20 °C / pH 6.7 / aq. phosphate buffer 8.1: hydrogenchloride / water / 10 h / Reflux 9.1: potassium tert-butylate / ethylene glycol dimethyl ether / 0.5 h / 20 °C 9.2: 12 h / Reflux 10.1: bis(acetato)bis(triphenylphosphine)palladium(0); potassium acetate / acetonitrile / 12 h / 100 °C / Inert atmosphere View Scheme

1.1: aq. KOH / ethanol / 12 h / Heating 2.1: aq. NaOH / dioxane / 12 h / 20 °C 3.1: CO(Im)2; MgCl2; Et3N / tetrahydrofuran / 24 h / 20 °C 4.1: 75 percent / NaH / dimethylformamide / 3 h / 20 °C 5.1: anisole / trifluoroacetic acid / 0.5 h / 0 °C 6.1: Et3N; DMAP / benzene / 1 h / 20 °C 7.1: 71 percent / EtONa / ethanol / 1 h / Heating 8.1: 87 percent / DDQ / dioxane / 4 h / Heating 9.1: 81 percent / NaOH / ethanol / 6 h / 0 °C 10.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 10.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 11.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 12.1: 60 percent / aq. HCl / 0.5 h / Heating 13.1: 64 percent / morpholine / toluene / 3 h / Heating 14.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 14.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: 64 percent / morpholine / toluene / 3 h / Heating 2.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 2.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: 84 percent / TsOH / benzene / 4 h / Heating 2.1: aq. KOH / ethanol / 12 h / Heating 3.1: aq. NaOH / dioxane / 12 h / 20 °C 4.1: CO(Im)2; MgCl2; Et3N / tetrahydrofuran / 24 h / 20 °C 5.1: 75 percent / NaH / dimethylformamide / 3 h / 20 °C 6.1: anisole / trifluoroacetic acid / 0.5 h / 0 °C 7.1: Et3N; DMAP / benzene / 1 h / 20 °C 8.1: 71 percent / EtONa / ethanol / 1 h / Heating 9.1: 87 percent / DDQ / dioxane / 4 h / Heating 10.1: 81 percent / NaOH / ethanol / 6 h / 0 °C 11.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 11.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 12.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 13.1: 60 percent / aq. HCl / 0.5 h / Heating 14.1: 64 percent / morpholine / toluene / 3 h / Heating 15.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 15.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: 64 percent / morpholine / toluene / 3 h / Heating 2.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 2.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: aq. NaOH / dioxane / 12 h / 20 °C 2.1: CO(Im)2; MgCl2; Et3N / tetrahydrofuran / 24 h / 20 °C 3.1: 75 percent / NaH / dimethylformamide / 3 h / 20 °C 4.1: anisole / trifluoroacetic acid / 0.5 h / 0 °C 5.1: Et3N; DMAP / benzene / 1 h / 20 °C 6.1: 71 percent / EtONa / ethanol / 1 h / Heating 7.1: 87 percent / DDQ / dioxane / 4 h / Heating 8.1: 81 percent / NaOH / ethanol / 6 h / 0 °C 9.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 9.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 10.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 11.1: 60 percent / aq. HCl / 0.5 h / Heating 12.1: 64 percent / morpholine / toluene / 3 h / Heating 13.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 13.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: 75 percent / NaH / dimethylformamide / 3 h / 20 °C 2.1: anisole / trifluoroacetic acid / 0.5 h / 0 °C 3.1: Et3N; DMAP / benzene / 1 h / 20 °C 4.1: 71 percent / EtONa / ethanol / 1 h / Heating 5.1: 87 percent / DDQ / dioxane / 4 h / Heating 6.1: 81 percent / NaOH / ethanol / 6 h / 0 °C 7.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 7.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 8.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 9.1: 60 percent / aq. HCl / 0.5 h / Heating 10.1: 64 percent / morpholine / toluene / 3 h / Heating 11.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 11.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: anisole / trifluoroacetic acid / 0.5 h / 0 °C 2.1: Et3N; DMAP / benzene / 1 h / 20 °C 3.1: 71 percent / EtONa / ethanol / 1 h / Heating 4.1: 87 percent / DDQ / dioxane / 4 h / Heating 5.1: 81 percent / NaOH / ethanol / 6 h / 0 °C 6.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 6.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 7.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 8.1: 60 percent / aq. HCl / 0.5 h / Heating 9.1: 64 percent / morpholine / toluene / 3 h / Heating 10.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 10.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme

1.1: ethyl chloroformate; Et3N / tetrahydrofuran / 0.5 h / 0 °C 1.2: 70 percent / tetrahydrofuran / 1 h / 20 °C 2.1: 55 percent / LiBH4 / dioxane / 0.5 h / 20 °C 3.1: 60 percent / aq. HCl / 0.5 h / Heating 4.1: 64 percent / morpholine / toluene / 3 h / Heating 5.1: [(CH3)3Si]2NLi / tetrahydrofuran / 0.5 h / -78 °C 5.2: 53 percent / (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine / tetrahydrofuran / 3 h / -78 °C View Scheme