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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
喜树碱
合成路线
（共 215 条）
125917-60-4
(2-氯-3-喹啉)甲醇
→
反应条件
7689-03-4
喜树碱
反应条件
1: PBr3 2: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 48 h / Heating 3: 59 percent / Pd(OAc)2, Bu4N(1+)*Br(1-), KOAc / dimethylformamide / 3 h / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 27 p. 10971 - 10972
935761-81-2
→
反应条件
7689-03-4
喜树碱
反应条件
methanol; ammonia in tetrahydrofuran 120 h; Product distribution / selectivity;
参考文献
Glyconix Corporation
Patent: US2007/99948 A1, 2007 ;
Location in patent: Page/Page column 21-22 ;
123948-88-9
托泊替康醋酸盐; 醋酸拓扑替康; 4-乙基-4,9-二羟基-10-[(二甲基氨基)甲基]-1H-吡喃并[3',4':6,7]中氮茚并[1,2-b]喹啉-3,14(4H,12H)-二酮醋酸盐
→
反应条件
942429-91-6
+
19685-09-7
羟基喜树碱
+
119413-54-6
拓普替康
+
7689-03-4
喜树碱
反应条件
hydrogenchloride in water 0.25 h;
参考文献
US2007/149783 A1, ;
Page/Page column title page; 7 ;
1085755-35-6
→
反应条件
7689-03-4
喜树碱
反应条件
hydrogenchloride in diethyl ether; ethanol Pinner reaction; Heating;
参考文献
Kanazawa, Alice; Muniz, Mauro N.; Baumlova, Barbora; Ljungdahl, Natalie; Greene, Andrew E.
Synlett, 2008 , # 15 p. 2275 - 2278
91421-43-1
9-氨基喜树碱
→
反应条件
67656-30-8
10-羟基喜树碱
+
7689-03-4
喜树碱
反应条件
sulfuric acid; sodium nitrite in water 1 h; Heating;
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
110351-94-5
7-乙基-10-羟基喜树碱中间体
+
529-23-7
2-氨基苯甲醛
→
反应条件
7689-03-4
喜树碱
反应条件
toluene-4-sulfonic acid in toluene 2 h; Heating;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2317 - 2319
939055-74-0
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: chloro(trimethyl)silane; sodium iodide; H2O / acetonitrile / 5 h / 65 °C 2.1: 70 percent / potassium carbonate; lithium bromide; tetrabutylammonium bromide / H2O; toluene / Heating 3.1: 94 percent / lithium hydroxide monohydrate / H2O; tetrahydrofuran / cooling 4.1: oxalyl chloride / CH2Cl2; dimethylformamide / cooling 5.1: NaHCO3 / CH2Cl2 / 20 °C 6.1: 98 percent / triphenylphosphine oxide; trifluoromethanesulfonic anhydride / CH2Cl2 / 0 - 20 °C 7.1: K3Fe(CN)6; potassium carbonate; CH3SO2NH2 / (DHQD)2-PYR; K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / 40 h / 0 °C 7.2: 71 percent / iodine; CaCO3 / methanol; H2O / 15 h / 40 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 10 p. 2003 - 2005
939055-75-1
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: 70 percent / potassium carbonate; lithium bromide; tetrabutylammonium bromide / H2O; toluene / Heating 2.1: 94 percent / lithium hydroxide monohydrate / H2O; tetrahydrofuran / cooling 3.1: oxalyl chloride / CH2Cl2; dimethylformamide / cooling 4.1: NaHCO3 / CH2Cl2 / 20 °C 5.1: 98 percent / triphenylphosphine oxide; trifluoromethanesulfonic anhydride / CH2Cl2 / 0 - 20 °C 6.1: K3Fe(CN)6; potassium carbonate; CH3SO2NH2 / (DHQD)2-PYR; K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / 40 h / 0 °C 6.2: 71 percent / iodine; CaCO3 / methanol; H2O / 15 h / 40 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 10 p. 2003 - 2005
939055-76-2
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: 94 percent / lithium hydroxide monohydrate / H2O; tetrahydrofuran / cooling 2.1: oxalyl chloride / CH2Cl2; dimethylformamide / cooling 3.1: NaHCO3 / CH2Cl2 / 20 °C 4.1: 98 percent / triphenylphosphine oxide; trifluoromethanesulfonic anhydride / CH2Cl2 / 0 - 20 °C 5.1: K3Fe(CN)6; potassium carbonate; CH3SO2NH2 / (DHQD)2-PYR; K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / 40 h / 0 °C 5.2: 71 percent / iodine; CaCO3 / methanol; H2O / 15 h / 40 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 10 p. 2003 - 2005
939055-77-3
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: oxalyl chloride / CH2Cl2; dimethylformamide / cooling 2.1: NaHCO3 / CH2Cl2 / 20 °C 3.1: 98 percent / triphenylphosphine oxide; trifluoromethanesulfonic anhydride / CH2Cl2 / 0 - 20 °C 4.1: K3Fe(CN)6; potassium carbonate; CH3SO2NH2 / (DHQD)2-PYR; K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / 40 h / 0 °C 4.2: 71 percent / iodine; CaCO3 / methanol; H2O / 15 h / 40 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 10 p. 2003 - 2005
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