2-氧代-4,6-二甲基-1,2-二氢吡啶-3-甲腈合成路线 （共 62 条）
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 67 percent / silver carbonate / benzene / 48 h 2: 92 percent / H2SO4; NBS / trifluoroacetic acid / 24 h / 20 °C View Scheme
参考文献
Mal, Prasenjit; Lourderaj; Parveen; Venugopalan; Moorthy, J. Narasimha; Sathyamurthy
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3446 - 3453
参考文献
Ried; Meyer
Chemische Berichte, 1957 , vol. 90, p. 2841,2846
反应条件
1: 97 percent / POCl3 / 3 h / Heating 2: 100 percent / conc. H2SO4 / 2 h / 120 °C View Scheme
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
1: 97 percent / POCl3 / 3 h / Heating 2: 100 percent / conc. H2SO4 / 2 h / 120 °C 3: 75 percent / Br2, aq. NaOH / 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 94 percent / sulfuryl chloride / CCl4 / 6 h / Heating 2: 76 percent / POCl3 / Heating 3: 91 percent / aq. H2SO4 / Heating View Scheme
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
参考文献
Ried; Meyer
Chemische Berichte, 1957 , vol. 90, p. 2841,2846
反应条件
bromine in acetic acid 0.5 h;
参考文献
Thompson, Wayne J.; Gaudino, John
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5237 - 5243
反应条件
sodium hydroxide T=170°C;
参考文献
Ried; Meyer
Chemische Berichte, 1957 , vol. 90, p. 2841,2846
参考文献
Moir
Journal of the Chemical Society, 1902 , vol. 81, p. 116
