2-氧代-4,6-二甲基-1,2-二氢吡啶-3-甲腈合成路线 （共 62 条）
参考文献
Mariella; Belcher
Journal of the American Chemical Society, 1951 , vol. 73, p. 2616
反应条件
hydrogenchloride; hydrogen; palladium(II) oxide hydrate in methanol; water T=20°C; 26 h; Inert atmosphere;
参考文献
US2014/107122 A1, ;
Paragraph 0154; 0155 ;
反应条件
1: acetic acid anhydride; fuming HNO3
2: chlorobenzene; PCl5
3: palladium/charcoal; platinum; ethanol / Hydrogenation
View Scheme
参考文献
van Wagtendonk; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1942 , vol. 61, p. 728,731
反应条件
1: trichlorophosphate; triethylamine / acetonitrile / 3 h / |Reflux
2: sodium carbonate / ethanol / 4 h / |Reflux
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参考文献
Waly, Mohamed A.; El-Hawary, Ibrahim I.; Hamama, Wafaa S.; Zoorob, Hanafi H.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # SUPPL.1 p. E12-E17
反应条件
1: 95 percent / Bromine / acetic acid / 0.5 h
2: 86 percent / POCl3/PCl5 / 8 h / Heating
3: 62 percent / 47percent aqueous HI/red phosphorus / 4 h / 140 °C
4: 4.5 g / KOH / H2O / 72 h / Heating
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参考文献
Thompson, Wayne J.; Gaudino, John
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5237 - 5243
反应条件
2: sulfuric acid
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参考文献
Ried; Meyer
Chemische Berichte, 1957 , vol. 90, p. 2841,2846
反应条件
1: PCl5
2: palladium/charcoal; aq.-ethanolic HCl / 1029.7 Torr / Hydrogenation
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参考文献
Yamamoto; Nishikawa
Yakugaku Zasshi, 1959 , vol. 79, p. 297,301
Chem.Abstr., 1959 , p. 15070
反应条件
1: 67 percent / silver carbonate / benzene / 48 h
2: 92 percent / H2SO4; NBS / trifluoroacetic acid / 24 h / 20 °C
3: 61 percent / dimethylformamide / 10 h / Heating
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参考文献
Mal, Prasenjit; Lourderaj; Parveen; Venugopalan; Moorthy, J. Narasimha; Sathyamurthy
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3446 - 3453
参考文献
Ried; Meyer
Chemische Berichte, 1957 , vol. 90, p. 2841,2846
反应条件
1: 54 percent / HNO3 / acetic anhydride / 1 h / 5 - 20 °C
2: 61 percent / POCl3 / 180 °C
View Scheme
参考文献
van Wagtendonk; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1942 , vol. 61, p. 728,731
