3,4,5,6,7,8-六氢薁-1(2H)-酮合成路线 （共 40 条）
反应条件
1: Zn(Cu) / diethyl ether / 5 h
2: diethyl ether / 1 h / 5 °C
3: Li2CO3 / dimethylformamide / 0.67 h / 80 °C
4: NaBH4, CeCl3 / methanol / 0.17 h / 20 °C
5: 80percent aq. formic acid / 0.67 h / 80 - 85 °C
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
反应条件
1: diethyl ether / 1 h / 5 °C
2: Li2CO3 / dimethylformamide / 0.67 h / 80 °C
3: NaBH4, CeCl3 / methanol / 0.17 h / 20 °C
4: 80percent aq. formic acid / 0.67 h / 80 - 85 °C
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
反应条件
1: NaBH4, CeCl3 / methanol / 0.17 h / 20 °C
2: 80percent aq. formic acid / 0.67 h / 80 - 85 °C
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
反应条件
1: Li2CO3 / dimethylformamide / 0.67 h / 80 °C
2: NaBH4, CeCl3 / methanol / 0.17 h / 20 °C
3: 80percent aq. formic acid / 0.67 h / 80 - 85 °C
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
反应条件
1: 83 percent / Ph3P / tetrahydrofuran / 1 h / 23 °C
2: 76 percent / DBU / tetrahydrofuran / 48 h / Ambient temperature
3: 42 percent / CrO3, H2SO4 / 48 h
4: 75 percent / K2CO3 / H2O / 4 h / Heating
View Scheme
参考文献
Yurdakul, Aycil; Gurtner, Christian; Jung, Elena-Silvia; Lorenzi-Riatsch, Annalaura; Linden, Anthony; Guggisberg, Armin; Bienz, Stefan; Hesse, Manfred
Helvetica Chimica Acta, 1998 , vol. 81, # 8 p. 1373 - 1392
反应条件
1: 76 percent / DBU / tetrahydrofuran / 48 h / Ambient temperature
2: 42 percent / CrO3, H2SO4 / 48 h
3: 75 percent / K2CO3 / H2O / 4 h / Heating
View Scheme
参考文献
Yurdakul, Aycil; Gurtner, Christian; Jung, Elena-Silvia; Lorenzi-Riatsch, Annalaura; Linden, Anthony; Guggisberg, Armin; Bienz, Stefan; Hesse, Manfred
Helvetica Chimica Acta, 1998 , vol. 81, # 8 p. 1373 - 1392
反应条件
1: 42 percent / CrO3, H2SO4 / 48 h
2: 75 percent / K2CO3 / H2O / 4 h / Heating
View Scheme
参考文献
Yurdakul, Aycil; Gurtner, Christian; Jung, Elena-Silvia; Lorenzi-Riatsch, Annalaura; Linden, Anthony; Guggisberg, Armin; Bienz, Stefan; Hesse, Manfred
Helvetica Chimica Acta, 1998 , vol. 81, # 8 p. 1373 - 1392
反应条件
1: 100 percent / bromine / diethyl ether
2: 91 percent / potassium t-butoxide / dimethylsulfoxide / 3 h / 50 °C
3: 47 percent Chromat. / 47percent hydrobromic acid / acetic acid / 3 h / 80 - 90 °C
View Scheme
参考文献
Hirano, Shigeo; Takagi, Seiji; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 1 p. 169 - 173
反应条件
1: 91 percent / potassium t-butoxide / dimethylsulfoxide / 3 h / 50 °C
2: 47 percent Chromat. / 47percent hydrobromic acid / acetic acid / 3 h / 80 - 90 °C
View Scheme
参考文献
Hirano, Shigeo; Takagi, Seiji; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 1 p. 169 - 173
反应条件
(i) AlCl3, NaOAc, (ii) CF3CO2H; Multistep reaction;
参考文献
Fristad,W.E. et al.
Tetrahedron Letters, 1979 , p. 1999 - 2002
