1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
1: POCl3 2: water 3: aqueous HCl; ethanol 4: Raney nickel; methanol / Hydrogenation 5: ethanol View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
toluene-4-sulfonic acid in water T=70°C; 24 h;
参考文献
Rahmati, Abbas; Khalesi, Zahra
Tetrahedron, 2012 , vol. 68, # 40 p. 8472 - 8479
反应条件
1: POCl3 2: H2O View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
1: 93 percent / water, POCl3 / Heating 2: 98 percent / conc. H2SO4, KNO3 / 1.) 15 min, 7 deg C, 2.) 30 min, 20 deg C 3: 30percent hydrazine / ethanol / 15 min, 20 deg C then 5 min, reflux 4: 60 percent / Na2S2O4, 10percent NH4OH / 50 deg C then 10 min, reflux View Scheme
参考文献
Kuz'menko, V. V.; Kuz'menko, T. A.; Aleksandrov, G. G.; Pozharskii, A. F.; Gulevskaya, A. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 6 p. 690 - 697
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 6 p. 836 - 844
反应条件
nitrogen(IV) oxide P=225.02 Torr; 4 h;
参考文献
Kaupp, Gerd; Schmeyers, Jens
Journal of Organic Chemistry, 1995 , vol. 60, # 17 p. 5494 - 5503
反应条件
triethylamine in chloroform T=20°C; 24 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 25, # 7.2 p. 1402 - 1405
Zhurnal Obshchei Khimii, , vol. 25, # 7 p. 1553 - 1557
反应条件
1: POCl3 View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
triethylamine in chloroform T=20°C; Rate constant;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Artem'eva, Z. L.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1402 - 1405
Zhurnal Obshchei Khimii, 1989 , vol. 25, # 7 p. 1553 - 1557
反应条件
triethylamine in chloroform T=20°C; 4 h; further alkyl iodides; Product distributionRate constant;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Artem'eva, Z. L.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1402 - 1405
Zhurnal Obshchei Khimii, 1989 , vol. 25, # 7 p. 1553 - 1557
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 1 h;
参考文献
Neumann, Donna M.; Cammarata, Amy; Backes, Gregory; Palmer, Glen E.; Jursic, Branko S.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 813 - 826
