1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
in N,N-dimethyl-formamide
T=160 - 170°C; 0.5 h;
参考文献
Hirota, Kosaku; Kitade, Yukio; Senda, Shigeo
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 345 - 347
反应条件
piperidine; pyridine
48 h; Heating;
参考文献
Molina; Vilaplana; Pastor
Synthesis, 1992 , # 9 p. 827 - 829
参考文献
Kreutzberger
Arzneimittel Forschung, 1978 , vol. 28, p. 1684,1686
参考文献
Clark-Lewis; Thompson
Journal of the Chemical Society, 1959 , p. 2401,2404
反应条件
acetic anhydride; acetic acid
参考文献
Clark-Lewis; Thompson
Journal of the Chemical Society, 1959 , p. 1628
反应条件
potassium hydroxide in ethanol
Reimer-Tiemann reaction; 3 h;
参考文献
Jursic, Branko S; Neumann, Donna M
Tetrahedron Letters, 2001 , vol. 42, # 48 p. 8435 - 8439
反应条件
orthoformic acid triethyl ester
T=120°C;
参考文献
Clark-Lewis; Thompson
Journal of the Chemical Society, 1959 , p. 2401,2404
参考文献
Clark-Lewis; Thompson
Journal of the Chemical Society, 1959 , p. 2401,2404
反应条件
1: trichlorophosphate / water / 3 h / Reflux
2: hydroxylamine hydrochloride; sodium acetate / isopropyl alcohol / 4 h / Reflux
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
in acetonitrile
T=20°C; Knoevenagel condensation;
参考文献
Wang, Qi-Fang; Hui, Li; Hou, Hong; Yan, Chao-Guo
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 260 - 265
