1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
1: N,N'-dimethyl-barbituric acid; acetone 2: With sulfuric acid; hydrogen; platinum on activated charcoal in water P=3878.61 Torr; 48 h;
参考文献
Jursic, Branko S.; Stevens, Edwin D.
Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2203 - 2210
反应条件
in methanol 5 h; Heating;
参考文献
Jursic, Branko S; Neumann, Donna M; Martin, Kenneth L; Stevens, Edwin D
Organic letters, 2002 , vol. 4, # 5 p. 811 - 813
反应条件
1: aniline With hydrogenchloride; sodium nitrite in water T=0°C; 2: N,N'-dimethyl-barbituric acid With sodium acetate in ethanol; water T=10°C;
参考文献
Xue, Mengzhu; Xu, Minghao; Lu, Weiqiang; Huang, Jin; Li, Honglin; Xu, Yufang; Liu, Xiaofeng; Zhao, Zhenjiang
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 4 p. 747 - 752
反应条件
sulfuric acid; nitric acid in water T=30 - 40°C; 4.5 h;
参考文献
Langlet, Abraham; Latypov, Nikolaj V.; Wellmar, Ulf; Bemm, Ulf; Goede, Patrick; Bergman, Jan; Romero, Ivan
Journal of Organic Chemistry, 2002 , vol. 67, # 22 p. 7833 - 7838
反应条件
1: benzaldehyde; malononitrile With sodium acetate in ethanol T=20°C; 0.5 h; 2: N,N'-dimethyl-barbituric acid With bromine; sodium ethanolate in ethanol 3 h;
参考文献
Vereshchagin, Anatolii N.; Elinson, Michail N.; Dorofeeva, Evgeniya O.; Stepanov, Nikita O.; Zaimovskaya, Tatiana A.; Nikishin, Gennady I.
Tetrahedron, 2013 , vol. 69, # 7 p. 1945 - 1952
反应条件
in water T=100°C; 0.5 h;
参考文献
Mohammed Khan, Khalid; Khan, Momin; Ali, Muhammad; Taha, Muhammad; Hameed, Abdul; Ali, Sajjad; Perveen, Shahnaz; Choudhary, M. Iqbal
Medicinal Chemistry, 2011 , vol. 7, # 3 p. 231 - 236
反应条件
sodium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) in dichloromethane
参考文献
Bjorsne, Magnus; Hoffmann, Kurt-Jurgen; Ponten, Fritiof; Strandlund, Gert; Svensson, Peder; Wilstermann, Michael
Patent: US2004/23971 A1, 2004 ;
反应条件
water; trichlorophosphate Heating;
参考文献
Kuz'menko, V. V.; Kuz'menko, T. A.; Aleksandrov, G. G.; Pozharskii, A. F.; Gulevskaya, A. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 6 p. 690 - 697
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 6 p. 836 - 844
反应条件
1: POCl3 2: water 3: aqueous HCl; ethanol 4: Raney nickel; methanol / Hydrogenation 5: formic acid View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
1: POCl3 2: methanol View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
