1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
1: trichlorophosphate / water / 3 h / Reflux 2: nitric acid / sulfuric acid / 2 h / 10 °C 3: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
T=100°C; 0.416667 h;
参考文献
Tetrahedron Letters, , vol. 48, # 12 p. 2159 - 2163
反应条件
1: N,N'-dimethyl-barbituric acid; acetone 2: With sulfuric acid; hydrogen; platinum on activated charcoal in water P=3878.61 Torr; 48 h;
参考文献
Jursic, Branko S.; Stevens, Edwin D.
Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2203 - 2210
参考文献
Deb, Mohit L.; Bhuyan, Pulak J.
Tetrahedron Letters, 2007 , vol. 48, # 12 p. 2159 - 2163
反应条件
in acetonitrile T=20°C; 6 h;
参考文献
Selic, Lovro; Stanovnik, Branko
Tetrahedron, 2001 , vol. 57, # 15 p. 3159 - 3164
反应条件
in diethyl ether T=20°C; 2 h;
参考文献
Obschestvo S Ogranichennoi Otvetstvennostju "Unikorm"; GRANIK, Vladimir Grigorevich; PARSHIN, Valery Aleksandrovich; GOLOVKO, Tatyana Vasilyevna; TUGUSHEVA, Nelya Zarifovna; MEDVEDEVA, Marina Igorevna
Patent: EP2564851 A2, 2013 ;
Location in patent: Paragraph 0014-0015 ;
反应条件
acetic anhydride T=90°C; Condensation; 2 h;
参考文献
Wuerthner, Frank
Synthesis, 1999 , # 12 p. 2103 - 2113
反应条件
in ethyl acetate 0.5 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Kantlehner, Willi; Hauber, Michael
Bulletin des Societes Chimiques Belges, 1994 , vol. 103, # 12 p. 697 - 704
参考文献
Deb, Mohit L.; Bhuyan, Pulak J.
Tetrahedron Letters, 2007 , vol. 48, # 12 p. 2159 - 2163
参考文献
Decicco; Nelson
Tetrahedron Letters, 1993 , vol. 34, # 51 p. 8213 - 8216
