1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
in acetonitrile T=20°C; Knoevenagel condensation; 2 h;
参考文献
Wang, Qi-Fang; Hui, Li; Hou, Hong; Yan, Chao-Guo
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 260 - 265
反应条件
1: 93 percent / water, POCl3 / Heating 2: 98 percent / conc. H2SO4, KNO3 / 1.) 15 min, 7 deg C, 2.) 30 min, 20 deg C View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
zinc(II) chloride T=100°C; 0.166667 h;
参考文献
Rao, P. Shanthan; Venkataratnam, R. V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 4 p. 484 - 486
反应条件
bromocyane; L-(+)-tartaric acid in methanol T=0 - 20°C; screw cap tube;
参考文献
Jalilzadeh, Mohammad; Pesyan, Nader Noroozi
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 9 p. 3382 - 3388
参考文献
Deb, Mohit L.; Bhuyan, Pulak J.
Tetrahedron Letters, 2007 , vol. 48, # 12 p. 2159 - 2163
反应条件
selenium(IV) oxide in 1,4-dioxane; water
Oxidation;
参考文献
Schank, Kurt; Lick, Carlo
Synthesis, 1983 , # 5 p. 392 - 395
反应条件
sulfuryl dichloride in tetrahydrofuran
T=85°C; 6 h; Inert atmosphere;
参考文献
Mallah, Eyad; Sweidan, Kamal; Engelmann, Joern; Steimann, Manfred; Kuhn, Norbert; Maier, Martin E.
Tetrahedron, 2012 , vol. 68, # 4 p. 1005 - 1010
反应条件
potassium chloride; dihydrogen peroxide; chloroperoxydase in water
参考文献
Franssen; Van der Plas
Recueil des Travaux Chimiques des Pays Bas, 1984 , vol. 103, # 3 p. 99 - 100
反应条件
triethylamine in chloroform
5 h; Heating;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Artem'eva, Z. L.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1402 - 1405
Zhurnal Obshchei Khimii, 1989 , vol. 25, # 7 p. 1553 - 1557
反应条件
triethylamine in chloroform
T=20°C; 4 h; further alkyl iodides; Product distributionRate constant;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Artem'eva, Z. L.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1402 - 1405
Zhurnal Obshchei Khimii, 1989 , vol. 25, # 7 p. 1553 - 1557
