N-苯甲酰基-3'-脱氧腺苷合成路线 （共 21 条）
反应条件
1: 69 percent / pyridine / 12 h / 0 °C 2: 70 percent / iPr2NEt / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
sodium hydroxide in tetrahydrofuran; methanol
T=0°C; 0.5 h;
参考文献
Meier; Neumann; Andre; Henin; Huynh-Dinh
Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7300 - 7308
反应条件
sodium methylate in methanol
T=20°C; 20 h;
参考文献
McDonald, Frank E.; Gleason, Mark M.
Journal of the American Chemical Society, 1996 , vol. 118, # 28 p. 6648 - 6659
反应条件
sodium hydroxide in pyridine; ethanol
0.75 h; Ambient temperature;
参考文献
Charubala; Uhlmann; Himmelsbach; Pfleiderer
Helvetica Chimica Acta, 1987 , vol. 70, # 8 p. 2028 - 2038
反应条件
ammonium hydroxide in methanol
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: OsO4, N-methylmorpholine N-oxide / tetrahydrofuran; 2-methyl-propan-2-ol; H2O / 4 h / 20 °C
2: Et3N / CH2Cl2 / 22 h / 20 °C
3: 65 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 3 h / Heating
4: 16 percent / NaOMe / methanol / 20 h / 20 °C
View Scheme
参考文献
McDonald, Frank E.; Gleason, Mark M.
Journal of the American Chemical Society, 1996 , vol. 118, # 28 p. 6648 - 6659
反应条件
1: 80 percent / Mo(CO)6, trimethylamine N-oxide, Et3N / diethyl ether / 20 °C
2: OsO4, N-methylmorpholine N-oxide / tetrahydrofuran; 2-methyl-propan-2-ol; H2O / 4 h / 20 °C
3: Et3N / CH2Cl2 / 22 h / 20 °C
4: 65 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 3 h / Heating
5: 16 percent / NaOMe / methanol / 20 h / 20 °C
View Scheme
参考文献
McDonald, Frank E.; Gleason, Mark M.
Journal of the American Chemical Society, 1996 , vol. 118, # 28 p. 6648 - 6659
反应条件
1: 65 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 3 h / Heating
2: 16 percent / NaOMe / methanol / 20 h / 20 °C
View Scheme
参考文献
McDonald, Frank E.; Gleason, Mark M.
Journal of the American Chemical Society, 1996 , vol. 118, # 28 p. 6648 - 6659
反应条件
1: 88 percent / pyridine / 2.5 h / 0 °C
2: 91 percent / 1.5 M aq. NaOH / methanol; tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Meier; Neumann; Andre; Henin; Huynh-Dinh
Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7300 - 7308
反应条件
2: aq. ammonium hydroxide / methanol
3: 99 percent / pyridine; DMAP
4: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
5: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
6: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
7: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
