N-苯甲酰基-3'-脱氧腺苷合成路线 （共 21 条）
反应条件
1: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
2: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
3: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
4: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
2: aq. ammonium hydroxide / methanol
3: 99 percent / pyridine; DMAP
4: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
5: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
6: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
7: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: aq. ammonium hydroxide / methanol
2: 99 percent / pyridine; DMAP
3: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
4: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
5: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
6: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: 99 percent / pyridine; DMAP
2: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
3: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
4: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
5: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
2: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
2: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
3: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
3: aq. ammonium hydroxide / methanol
4: 99 percent / pyridine; DMAP
5: 84 percent / H2O / acetonitrile / 9.5 h / 0 - 20 °C
6: 92 percent / tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / toluene / 0.83 h / 95 °C
7: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 °C
8: 100 percent / aq. ammonia / methanol
View Scheme
参考文献
Cui, Zhiyong; Zhang, Lei; Zhang, Biliang
Tetrahedron Letters, 2001 , vol. 42, # 4 p. 561 - 563
反应条件
1: 61 percent / TMSOTf / acetonitrile / 12 h / 55 °C
2: 77 percent / NaOH / ethanol; pyridine / 0.08 h / Ambient temperature
3: 1.) NaIO4, 2.) NaBH4 / 1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min
View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
1: 77 percent / NaOH / ethanol; pyridine / 0.08 h / Ambient temperature
2: 1.) NaIO4, 2.) NaBH4 / 1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min
View Scheme
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
反应条件
sodium tetrahydroborate; sodium periodate
1.) THF, H2O, room temperature, 2 h, 2.) MeOH, room temperature, 30 min; Yield given. Multistep reaction;
参考文献
Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M.
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530
