反应条件
1: 1.) n-BuLi, HMPA / 1.) THF, hexane, 20 min, 2.) THF, hexane, RT, 17 h
2: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
3: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
4: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
