2-氯-4-氧-6-氟喹唑啉合成路线 （共 3 条）
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; 4 h;
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
反应条件
1: 70 percent / POCl3; N,N-dimethylaniline / 16 h / Heating 2: 95 percent / aq. NaOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
1: 200 °C 2: 70 percent / POCl3; N,N-dimethylaniline / 16 h / Heating 3: 95 percent / aq. NaOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
