N-[2-(3,4-二甲氧基苯基)乙基]-3-(4-三氟甲基苯基)丙酰胺合成路线 (共 3 条)
反应条件
sodium methylate in methanol; toluene
T=110°C; P=760.051 Torr;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/83899 A2, 2009 ;
Location in patent: Page/Page column 7; 18 ;
Title/Abstract Full Text Show Details
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/83903 A1, 2009 ;
Location in patent: Page/Page column 7; 18 ;
反应条件
in toluene
90 h; Reflux; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD; ERBECK, Silke; KOBERSTEIN, Ralf; SOI, Antonio; ZISTLER, Andrea
Patent: WO2010/64212 A1, 2010 ;
Location in patent: Page/Page column 25 ;
反应条件
1: trichlorophosphate
2: formic acid; triethylamine; [RuCl(η6-p-cymene)(N-tosyl-1,2-diphenylethylenediamine)] / ethyl acetate / 40 h / 23 °C / |Large scale
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参考文献
Verzijl, Gerard K. M.; De Vries, Andre H. M.; De Vries, Johannes G.; Kapitan, Peter; Dax, Thomas; Helms, Matthias; Nazir, Zarghun; Skranc, Wolfgang; Imboden, Christoph; Stichler, Juergen; Ward, Richard A.; Abele, Stefan; Lefort, Laurent
Organic Process Research and Development, 2013 , vol. 17, # 12 p. 1531 - 1539