4-氨基-3-硝基苯甲酸乙酯合成路线 （共 15 条）
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Naim, S. Shawkat; Singh, Sudhir K.; Sharma, Satyavan; Gupta, Suman; Fatma, N.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1106 - 1109
参考文献
Ritsert; Epstein
Patent: DE151725 ;
反应条件
1: Raney nickel; methanol / Hydrogenation 2: disodium-salt of/the/ 1,2-dihydroxy-ethane-1,2-disulfonic acid; H2O View Scheme
参考文献
Silk
Journal of the Chemical Society, 1956 , p. 2058,2060
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.; Daicel Chemical Industries, Ltd.
Patent: EP1132087 A1, 2001 ;
反应条件
1: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 2: toluene / 2 h / Heating View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: With hydrogenchloride in diethyl ether
16 h; Heating / reflux;
2: With sodium hydroxide in dichloromethane; water
参考文献
Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst
Patent: US2007/191603 A1, 2007 ;
Location in patent: Page/Page column 27 ;
反应条件
sodium hydroxide; sulfuric acid in ethanol; water
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.; Daicel Chemical Industries, Ltd.
Patent: EP1132087 A1, 2001 ;
反应条件
sulfuric acid
T=100°C; 0.25 h;
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
ammonia
T=150°C; im Druckrohr;
参考文献
Grohmann
Chemische Berichte, 1890 , vol. 23, p. 3446
反应条件
ammonia
T=130 - 140°C;
参考文献
Thieme
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 464
