3-氧代-4-(2,4,5-三氟苯基)丁酸甲酯合成路线 （共 12 条）
反应条件
1: 2-(2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole in acetonitrile 3.5 h; 2: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=50°C; 8 h; 3: in acetonitrile T=30°C; 26 h;
参考文献
Kubryk, Michele; Hansen, Karl B.
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 205 - 209
反应条件
1: 2-(2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=0 - 20°C; 2: magnesium salt of monomethyl malonic acid in tetrahydrofuran T=20°C; 24 h;
参考文献
CHIRAL QUEST, INC.; WU, Shulin; YU, Bo; WANG, Yejing; DELICE, Alain; ZHU, Jingyang
Patent: WO2010/78440 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
methanol T=60 - 63°C;
参考文献
GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; GADAKAR, Maheshkumar; BHOSLE, Priyanka; SHINDE, Suresh
Patent: WO2010/131025 A1, 2010 ;
Location in patent: Page/Page column 26 ;
反应条件
potassium dichromate; sulfuric acid; acetic acid T=25 - 30°C; 24 h;
参考文献
WO2010/122578 A2, ;
Page/Page column 65 ;
反应条件
in toluene 3 h; Heating;
参考文献
Ahn, Jin Hee; Shin, Mi Sik; Jun, Mi Ae; Jung, Sun Ho; Kang, Seung Kyu; Kim, Kwang Rok; Rhee, Sang Dal; Kang, Nam Sook; Kim, Sun Young; Sohn, Sang-Kwon; Kim, Sung Gyu; Jin, Mi Sun; Lee, Jie Oh; Cheon, Hyae Gyeong; Kim, Sung Soo
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2622 - 2628
反应条件
methanesulfonic acid Reflux;
参考文献
WO2010/122578 A2, ;
Page/Page column 44 ;
反应条件
1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C 2: 88.7 percent / toluene / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2622 - 2628
反应条件
1: 2-(2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole in acetonitrile 3.5 h; 2: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=50°C; 8 h; 3: in acetonitrile T=30°C; 26 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 2 p. 205 - 209
反应条件
dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen in methanol; acetic acid T=70°C; P=3620.13 Torr; Inert atmosphereAutoclave;
参考文献
Sathe, Dhananjay Govind; Damle, Subhash Vishwanath; Arote, Nitin Dnyaneshwar; Ambre, Rakesh Ramchandra; Want, Kamlesh Digambar; Naik, Tushar Anil
Patent: US2013/158265 A1, 2013 ;
Location in patent: Paragraph 0161; 0162; 0163; 0164 ;
反应条件
1.1: hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / methanol; acetic acid / 70 °C / 3620.13 Torr / |Inert atmosphere; |Autoclave 2.1: lithium hydroxide hydrate; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-dichloroethylene / 3 h / 20 - 22 °C 2.2: 18.5 h / 10 - 20 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 3.2: 3 h / 0 - 5 °C 4.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 5.1: sodium hydroxide / water / 1 h / 0 - 5 °C 6.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme
参考文献
Sathe, Dhananjay Govind; Damle, Subhash Vishwanath; Arote, Nitin Dnyaneshwar; Ambre, Rakesh Ramchandra; Want, Kamlesh Digambar; Naik, Tushar Anil
Patent: US2013/158265 A1, 2013 ;
