(S)-Alpha-(硫代醋酸基)苯丙酸合成路线 （共 20 条）
反应条件
sodium chloride; sodium thiosulfate in N-methyl-acetamide; water
参考文献
Amano, Susumu; Mitsuda, Masaru; Inoue, Kenji; Kinoshita, Koichi; Yamashita, Koki; Ueda, Yasuyoshi
Patent: US2003/144546 A1, 2003 ;
反应条件
potassium carbonate in sodium hydroxide; water
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA, RECHERCHE MEDICALE (INSERM)
Patent: EP524553 A1, 1993 ;
反应条件
1: NaNO2; HCl / 0 - 20 °C 2: dimethylformamide / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2853 - 2861
反应条件
in methanol 12 h; Ambient temperature;
参考文献
Spaltenstein; Leban; Furfine
Tetrahedron Letters, 1993 , vol. 34, # 9 p. 1457 - 1460
反应条件
in water; ethyl acetate
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219
反应条件
Lipozyme lipase enzyme in phosphate buffer; acetonitrile T=20°C; pH=4.0; 40 h;
参考文献
Tetrahedron Letters, , vol. 43, # 42 p. 7585 - 7587
反应条件
1: HBr; sodium nitrite / H2O; toluene / 6 h / -5 - 15 °C 2: 66 percent / various solvent(s) / 24 h View Scheme
参考文献
Organic Letters, , vol. 6, # 19 p. 3233 - 3235
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran 1.) 0 deg C, 15 min; 2.) 0 deg C; 15 min without cooling; Title compound not separated from byproducts;
参考文献
Strijtveen, Bert; Kellog, Richard M.
Recueil des Travaux Chimiques des Pays-Bas, 1987 , vol. 106, # 10 p. 539 - 542
反应条件
in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Organic Letters, , vol. 4, # 12 p. 2047 - 2050
