4-(3-甲基-2-丁烯-2-基)吗啉合成路线 (共 3 条)
反应条件
sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=20°C; Buchwald-Hartwig amination; 8 h;
参考文献
Reddy, Ch. Venkat; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3047 - 3062
反应条件
titanium tetrachloride in hexane
T=0°C; 1 h; Reflux;
参考文献
Kosobokov, Mikhail D.; Dilman, Alexander D.; Struchkova, Marina I.; Belyakov, Pavel A.; Hu, Jinbo
Journal of Organic Chemistry, 2012 , vol. 77, # 4 p. 2080 - 2086
反应条件
titanium tetrachloride in hexane
T=70°C; 0.25 h; optimization procedure; other ketones, other reagent concentration; Product distribution;
参考文献
Carlson, Rolf; Nilsson, Asa; Stroemqvist, Mats
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 1 p. 7 - 14