L-(-)-3-N-Boc-氨基-2-氮杂丙酮合成路线 （共 8 条）
反应条件
aminosulfonic acid T=25 - 28°C; 0.05 h;
参考文献
Upadhyaya, Dharita J.; Barge, Alessandro; Stefania, Rachele; Cravotto, Giancarlo
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8318 - 8322
反应条件
sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate in N,N-dimethyl-formamide T=20°C; Cyclization; 12 h;
参考文献
Amblard, Muriel; Daffix, Isabelle; Berge, Gilbert; Calmes, Monique; Dodey, Pierre; Pruneau, Didier; Paquet, Jean-Luc; Luccarini, Jean-Michel; Belichard, Pierre; Martinez, Jean
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4193 - 4201
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Ogura, Haruo; Takeda, Kazuyoshi
Heterocycles, 1981 , vol. 15, # 1 p. 467 - 468
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 8 h;
参考文献
Kawabata, Takeo; Matsuda, Seiji; Kawakami, Shimpei; Monguchi, Daiki; Moriyama, Katsuhiko
Journal of the American Chemical Society, 2006 , vol. 128, # 48 p. 15394 - 15395
反应条件
1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C 2: 74 g / H2 / Pd-C / ethyl acetate / 8 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 48 p. 15394 - 15395
反应条件
1: 100 percent / pyridine 2: 90 percent / H2 / 10percent Pd-C / ethyl acetate View Scheme
参考文献
Heterocycles, , vol. 15, # 1 p. 467 - 468
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 1.2: 95 percent / tetrahydrofuran / 5 h / 20 °C 2.1: 96 percent / H2 / 10 percent Pd/C / ethanol / 20 °C View Scheme
参考文献
Amblard, Muriel; Daffix, Isabelle; Berge, Gilbert; Calmes, Monique; Dodey, Pierre; Pruneau, Didier; Paquet, Jean-Luc; Luccarini, Jean-Michel; Belichard, Pierre; Martinez, Jean
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4193 - 4201
反应条件
1: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 2: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Le Diguarher, Thierry; Ortuno, Jean-Claude; Dorey, Gilbert; Shanks, David; Guilbaud, Nicolas; Pierre, Alain; Fauchere, Jean-Luc; Hickman, John A.; Tucker, Gordon C.; Casara, Patrick J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3193 - 3204
