反应条件
1: thionyl chloride / methanol / 4 h / |Reflux
2: potassium permanganate; 18-crown-6 ether / water; tert-butyl alcohol / 2.33 h / 20 - 75 °C
3: ammonium chloride; HATU; N-ethyl-N,N-diisopropylamine / dichloromethane
4: N,N-dimethyl-formamide / 3 h / 20 °C
View Scheme
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131017 A1, 2013 ;