D-3-(2-萘基)-丙氨酸合成路线 （共 16 条）
反应条件
1: (S)-α,α-diphenylprolinol - n-butylboronic acid catalyst, catecholborane / CH2Cl2 / 1.7 h / -23 °C 2: 84 percent / NaN3, NaOH, H2O / 1,2-dimethoxy-ethane / 24 h / 23 °C 3: 88 percent / H2 / 10percent Pd/C / ethyl acetate / 13 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 5 p. 1906 - 1908
反应条件
1: 84 percent / NaN3, NaOH, H2O / 1,2-dimethoxy-ethane / 24 h / 23 °C 2: 88 percent / H2 / 10percent Pd/C / ethyl acetate / 13 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 5 p. 1906 - 1908
反应条件
oxygen; D-amino acid oxidase (M213G mutant, Rhodotorula gracilis) in phosphate buffer T=25°C; pH=8.5; 0.416667 h; Enzymatic reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 15 p. 2183 - 2190
反应条件
1: 70 percent / conc. HCl / H2O; ethanol / 12 h / Heating 2: O2 / D-amino acid oxidase (M213G mutant, Rhodotorula gracilis) / aq. phosphate buffer / 0.42 h / 25 °C / pH 8.5 / Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 15 p. 2183 - 2190
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
1: 80 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature 2: 97 percent / 0.17 h / 160 °C 3: 88 percent 4: 92 percent / 6 N aq. HCl / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 92 percent / EtONa / ethanol / 6 h / Heating 2: 80 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature 3: 97 percent / 0.17 h / 160 °C 4: 88 percent 5: 92 percent / 6 N aq. HCl / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 88 percent 2: 92 percent / 6 N aq. HCl / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 74, # 3-4 p. 184 - 191
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 74, # 3-4 p. 184 - 191
