2-氨基-4-溴-6-甲基苯并噻唑合成路线 （共 8 条）
反应条件
tert.-butylnitrite in 1,4-dioxane T=60°C; 1 h;
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 49 ;
US 20090130076 A1
反应条件
bromine in chloroform
T=20°C; 2 h;
参考文献
LUCKY, LTD.
Patent: EP590610 A1, 1994 ;
反应条件
bromine in acetic acid
T=5 - 20°C; 1 h;
参考文献
Bhagat; Deshmukh; Kuberkar
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 873 - 876
反应条件
1: 84 percent / HBr / H2SO4 / 2 h / 80 °C
2: 92 percent / Br / CHCl3 / 2 h / 20 °C
View Scheme
参考文献
Ra, Choon Sup; Jung, Bon Young; Park, Gyoosoon
Heterocycles, 2004 , vol. 62, p. 793 - 802
反应条件
1.1: aq. sulfuric acid / 20 h / 85 °C
1.2: 78.5 percent / toluene / 1 h / Heating
2.1: 84 percent / HBr / H2SO4 / 2 h / 80 °C
3.1: 92 percent / Br / CHCl3 / 2 h / 20 °C
View Scheme
参考文献
Ra, Choon Sup; Jung, Bon Young; Park, Gyoosoon
Heterocycles, 2004 , vol. 62, p. 793 - 802
反应条件
1: bromine / acetic acid
2: sodium hydroxide; hydrogenchloride / water
3: bromine / acetic acid / 1 h / 5 - 20 °C
View Scheme
参考文献
Bhagat; Deshmukh; Kuberkar
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 873 - 876
反应条件
1: sodium hydroxide; hydrogenchloride / water
2: bromine / acetic acid / 1 h / 5 - 20 °C
View Scheme
参考文献
Bhagat; Deshmukh; Kuberkar
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 873 - 876
反应条件
sodium hydroxide in acetonitrile
1 h; Heating;
参考文献
Ra, Choon Sup; Jung, Bon Young; Park, Gyoosoon
Heterocycles, 2004 , vol. 62, p. 793 - 802
