7-氯-1-乙基-6-氟-1,4-二氢-4-羰基喹啉-3-羧酸合成路线 （共 3 条）
反应条件
1: 65 percent / H2SO4 (d=1.83) / H2O / 1 h / Heating
2: 22 percent / CrO3 / acetic acid / 0.5 h / Ambient temperature
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参考文献
Lafont; Cave; Lambrey; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 163 - 168
反应条件
1: 65 percent / H2SO4 (d=1.83) / H2O / 1 h / Heating
2: 30 percent / Na2CO3 / H2O / 2 h / 100 °C / pH 14
View Scheme
参考文献
Lafont; Cave; Lambrey; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 163 - 168
反应条件
1: 65 percent / H2SO4 (d=1.83) / H2O / 1 h / Heating
2: 63 percent / 12 h / Heating
3: 23 percent / CrO3 / acetic acid / 0.5 h / 60 °C
4: 20 percent / 1.) 0.1 N Na2CO3; 2.) H2SO4 / 1.) 4 h; 2.) 2 h
View Scheme
参考文献
Lafont; Cave; Lambrey; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 163 - 168
