2-甲基-丙酸3-羟基-2,2,4-三甲基戊基酯合成路线 （共 13 条）
反应条件
toluene-4-sulfonic acid in toluene
参考文献
Baltz,H. et al.
Journal fuer Praktische Chemie (Leipzig), 1965 , vol. 29, p. 250 - 258
参考文献
Brauchbar; Kohn
Monatshefte fuer Chemie, 1898 , vol. 19, p. 34
参考文献
Brauchbar; Kohn
Monatshefte fuer Chemie, 1898 , vol. 19, p. 34
参考文献
Lesch; Michel
Monatshefte fuer Chemie, 1905 , vol. 26, p. 429
反应条件
pyridine 1-oxide; dodecacarbonyltriiron in benzene
T=80°C; 15 h; Yield given;
参考文献
Ito, Keiji; Kamiyama, Nobuhiro; Nakanishi, Saburo; Otsuji, Yoshio
Chemistry Letters, 1983 , p. 657 - 660
反应条件
potassium hydroxide; diethyl ether
T=10°C;
参考文献
Grignard; Iliesco
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1930 , vol. 190, p. 557
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With potassium hexamethylsilazane in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran
T=55°C; Inert atmosphere; Reagent/catalyst; Overall yield = 92.5 percent; Overall yield = 6.637 g;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
O2W(1-)*Li(1+) in tetrahydrofuran
T=40°C; 24 h; variation of temperature; Yields of byproduct given;
参考文献
Villacorta, Gilberto M.; Filippo, Joseph San
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1151 - 1154
反应条件
sodium hydroxide in water
T=60°C; 4 h; Concentration; Overall yield = 63.6 percentChromat.;
参考文献
Li, Yu-Gang; Luo, Chen-Xi; Qian, Chao; Chen, Xin-Zhi
Chemical Papers, 2014 , vol. 68, # 3 p. 422 - 426
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With n-butyllithium in tetrahydrofuran
Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran
0.533333 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
