1,1,1-三(羟甲基)乙烷合成路线 （共 76 条）
反应条件
1: 1,1,1-tris(hydroxymethyl)-ethane With potassium hydroxide; carbonic acid diethyl ester Cyclization; 2: With sodium hydroxide; p-toluenesulfonyl chloride Substitution; 3: potassium phtalimide Substitution; Further stages.;
参考文献
Kanoh, Shigeyoshi; Nishimura, Tomonari; Kita, Yukiko; Ogawa, Hiroshi; Motoi, Masatoshi; Takani, Masako; Tanaka, Toshiyuki
Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 2253 - 2256
反应条件
sodium hydride 1.) THF, reflux, 2.) THF, reflux; Multistep reaction. Title compound not separated from byproducts;
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1992 , vol. 46, # 3 p. 271 - 277
反应条件
pyridine; trichlorophosphate in acetonitrile
参考文献
Kim, Jeong Han; Gallagher, Michael J.; Toia, Robert F.
Australian Journal of Chemistry, 1994 , vol. 47, # 4 p. 715 - 722
反应条件
1: 81 percent / pyrydine / CHCl3 2: 1.) NaH / 1.) THF, reflux, overnight, 2.) THF, reflux, 24 h View Scheme
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1991 , vol. 45, # 1 p. 82 - 91
反应条件
potassium hydroxide in water; toluene T=15 - 25°C; 4.83333 h; Product distribution / selectivity;
参考文献
FUJIFILM Corporation
Patent: US2009/143623 A1, 2009 ;
Location in patent: Page/Page column 5 ;
反应条件
1: pyridine / 24 h / 10 °C 2: NaN3 / bis-(2-hydroxy-ethyl) ether / 16 h / 135 °C 3: LiAlH4 / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Tan, Kel Vin; Pellegrini, Paul A.; Skelton, Brian W.; Hogan, Conor F.; Greguric, Ivan; Barnard, Peter J.
Inorganic Chemistry, 2014 , vol. 53, # 1 p. 468 - 477
反应条件
In(OSO2CF3)3 in acetonitrile T=20°C; Acetylation;
参考文献
Chauhan, Kamlesh K.; Frost, Christopher G.; Love, Ian; Waite, David
Synlett, 1999 , # 11 p. 1743 - 1744
反应条件
triethylamine in tetrahydrofuran; methanol T=20°C; 16 h;
参考文献
Guzman-Duran, Antonio; Guzman, Esther; Pannell, Keith H.; Lloyd, Winston D.
Synthetic Communications, 2003 , vol. 33, # 19 p. 3271 - 3283
反应条件
1: 1.) NaH / 1.) THF, reflux, 2.) THF, reflux
2: 1.) NaH / 1.) THF, reflux, overnight, 2.) THF, reflux, 1 d
View Scheme
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1992 , vol. 46, # 3 p. 271 - 277
反应条件
sodium hydride
1.) THF, reflux, 2.) THF, reflux; Multistep reaction. Title compound not separated from byproducts;
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1992 , vol. 46, # 3 p. 271 - 277
